Effects of the use of EPAP (Expiratory Positive Airway Pressure) on exercise tolerance in patients with heart failure
- By Medicine Mates
- Posted 1686 days ago
Print version ISSN 1517-8692
Rev Bras Med Esporte vol.19 no.2 São Paulo Mar./Apr. 2013
EXERCISE AND SPORTS MEDICINE CLINIC
Effects of the use of EPAP (Expiratory Positive Airway Pressure) on exercise tolerance in patients with heart failure
Claudia ThofehrnI; Mario Sérgio Soares de Azeredo CoutinhoII; Clarissa Borguezan DarosIII; Amberson Vieira de AssisIII; Renata Moraes de LimaIV; Christiani Decker Batista BoninV; Magnus BenettiVI
IPhysiotherapy, Institute of Cardiology of Santa Catarina – São José, SC, Brazil
IIMedicine, Federal University of Santa Catarina – Florianópolis, SC, Brazil
IIIMedicine, Institute of Cardiology of Santa Catarina – São José, SC, Brazil
IVPhysiotherapy, Estácio de Sá College, Florianópolis – SC, Brazil
VPhysiotherapy, University of the State of Santa Catarina – Florianópolis, SC, Brazil
VIPhysical Education, University of the State of Santa Catarina – Florianópolis, SC, Brazil
INTRODUCTION: New therapeutic approaches that aim to improve the sensation of dyspnea and fatigue in patients with heart failure, as the application of expiratory positive airway pressure (EPAP) should be tested in an attempt to improve functional capacity and quality of life.
OBJECTIVE: To evaluate the effects of the use of EPAP during exercise in patients with heart failure functional class II and III (NYHA).
METHODS: Of 390 patients, 28 were selected with LVEF <40%. The six-minute walk test (6'WT) was performed three times with and without the EPAP, reflecting the greater distance in the analysis. The comparison between the data obtained was performed by paired t test or Wilcoxon test as the normality of the data.
RESULTS: The use of EPAP increased volume without significant minutes, but the perceived exertion was higher after the walk with the use of the mask when compared in the absence of a mask. There was significant increase in oxygen saturation compared with the group that did not use the mask. There was no improvement in distance walked in 6'WT with the use of EPAP.
CONCLUSION: Use of EPAP mask increases the perception of ventilatory effort and work, but its applicability in routine cardiac rehabilitation programs based on our preliminary data is questionable.
Keywords: heart failure, expiratory positive pressure airway, exercise.
The diseases of the circulatory system composed the third highest cause for hospital submissions by the Unified Health System (SUS) in Brazil between the years of 2000 and 2007. Heart failure (HF) is the most frequent among these, being responsible for over 2.7 million of submissions and is equivalent to 29.35% of the total by cardiovascular diseases and 3.0% of the general total1. In the year of 2003, the heart and coronary insufficiencies appear as the most expensive diseases in men and women aged between 60 and 80 years2.
Heart failure (HF) is a complex clinical syndrome result of any functional or structural heart disorder which harms ventricular performance. The clinical manifestations are dyspnea and fatigue, which may limit tolerance to exercise, cause fluid retention and lead to pulmonary congestion as well as strength and resistance of ventilator muscles decrease. Weakness of the ventilator musculature is directly associated with HF progression3-5.
Studies have shown that the use of Expiratory Positive Airway Pressure (EPAP) promotes significant improvement of the gas exchange, reduction of dyspnea and of ventilatory work, providing increase of the training threshold through maintenance of the positive pressure in the airway in the expiratory phase6-8. To verify the EPAP use, the 6-minute walk test (6'WT) is well-tolerated by the patients for measurement of the functional capacity8-11. When EPAP is applied to patients with HF, it presents high reproducibility and good correlation with the variables measured in the test of cardiopulmonary exercise12-14.
Thus, the aim of this study was to verify the effects of the expiratory positive airway pressure through the use of a mask promoter of EPAP during physical effort in individuals with HF functional class II and III (NYHA).
The EPAP kit used was by NewMed®, with adjustable PEEP valve from five to 20 cmH2O.Six-minute walk test
The walk test was performed according to the guidelines from the American Thoracic Society15. The equipment needed for the test performance was: a timer (Sport Timer®), tape measure, pulse oximeter (OxyWatch®), heart rate monitor (Polar®), aneroid esphygmomanometer (Diasyst®) and stethoscope (Littmann®), scale with stadiometer (scale Welmy®).
The test was performed using a 30-meter flat and covered corridor, marked with two cones, without external interferences, at least two hour prior to the meals. The individual had no previous warm-up and was told to walk the longest distance possible, having received standard verbal encouragement repeated at every minute: (first minute) "You are doing fine"; (second minute) "Keep it up"; (third minute)"You are doing fine, we are half way the test", (fourth minute) "Keep walking, only two minutes to go"; (fifth minute) "Is everything ok? The test is almost done". Three tests were performed where the first one had the aim of teaching and adapting. A 30-minute interval was observed between them. After the walk test for teaching, the two remaining ones (with and without the EPAP mask) had their performance sequence established by draw in order to minimize occasional bias15.
Vital data as systemic blood pressure, heart rate, respiratory rate, dyspnea level (Borg's scale) and oxygen saturation were verified before, during and after the test. The test was ended when the patient completed the six minutes or if there was angina, intense dyspnea, dizziness, sudoresis, pale or cyanotic appearance15.Study population
From a total of 390 patients followed in the Immediate Care Unit of Myocardiopathies of the Institute of Cardiology of Santa Catarina (AM – ICSC), patients with systolic dysfunction and left ventricular ejection fraction (LVEF) below 40%, myocardiopathy of any etiology; sinusal cardiac rhythm, functional class II and III (NYHA), stable, with no history of hospital submission in the last three months through data analysis of the medical reports, complementary examinations and medication treatment currently established, and who signed the free and clarified consent form, were selected.
Patients with disturb of the cardiac rhythm, active smoking, non-controlled systemic blood hypertension, aassociated pulmonary diseases, neurological and/or orthopedic limitations which made the six-minute walk test performance impossible were excluded.
The research was approved by the Ethics and Research in Humans Committee, Institute of Cardiology of Santa Catarina, São José, SC, according to the resolution of the National Health Board 196/96.Study type
This investigation was a clinical, prospective and controlled assay with random order of application of the tests.Study protocol
The effects of the EPAP application during effort in individuals with HF functional class II and III (NYHA) were assessed.
The three tests with each patient were performed on the same day. Concerning the tests order, a draw defined the tests performance sequence with or without the mask. When the first participant started with the mask on, the following one started the test without the mask. All patients were followed and monitored during the performance of each test; after the performance, the patient would sit, the mask was removed (in case it was being used) and the data were collected. The interval between tests was of 30' for stabilization of the vital signs and possible ventilatory alterations.
The pressure used on the EPAP mask was of 8 cmH2O, and each patient performed five minutes of adaptation to the mask and to the pressoric level before the TC6'. The three tests with each patient were performed on the same day.
The Borg's scale used had score between zero and ten; the higher the value, the more intense was the patient's effort. Ventilometry was used through the Wright Respirometer Mark 8 Ferraris®, ventilometer for determination of the volume-minute14,15.
The expected walked distance was obtained through the reference equations for distance prediction, according to Enright and Sherrill16, and is as follows:
ED = (7.57 x height cm) - (5.02 x age) - (1.76 x weight kg) - 309 m.
ED = (2.11 x height cm) - (2.29x weight kg) - (5.78 x age) + 667 m.
ED = Expected distance in the 6'WT.Statistical analysis
The data concerning the category variables were described by absolute and percentage frequency, while the continuous variables by measurements of central position (mean and median) and dispersion (standard deviation and interquartile range).The Wilcoxon test and two-way Analysis of Variance for repeated measures, with Bonferroni post hoc test were used for statistical analysis of the remaining data. The significance level adopted was of 5%.
A total of 28 patients were selected in the period between April and November, 2011. Mean age was of 50.57 ± 11.08 years, being 23 men (82.14%) and five women (17.86%). It was also verified that 19 patients (68.0%) presented FC II and nine (32.0%) FC III. The LVEF mean was of 27.14% (SD = ± 6.86%).
Based on the participants' weight and height (means of 81.04 ± 13.28 kg and 167.21 ± 7.45 cm, respectively), the expected walked distance whose mean was 576.07 (± 79.63) meters was measured. The low normality thershold was of 425.57 ± 80.06 meters.
Figure 1 presents the confidence intervals of the measurements of the distance walked with and without the use of the EPAP, whose means were respectively 431.07 ± 71.79 and 420.57 ± 79.28 meters.
Figure 1 verified there was no significant difference in the distance walked between patients who used or not the EPAP.
Table 1 demonstrates the comparison of the variables with and without the use of EPAP, at the pre-test, post-test and recovery conditions (after five minutes).
The factor group with and without EPAP mask played influence on the variables dyspnea and oxygen saturation, where the tiredness sensation was higher at the situation without use of EPAP, while the highest oxygen saturation occurred during the use of the EPAP mask.
In the main factor period of evaluation (pre-test, post-test and recovery), the variables systolic blood pressure, heart rate, dyspnea and ventilometry presented statistically significant difference. In the experiment without mask, the post hoc test pointed out that the heart rate was higher in the post-test than in the pre-test. Concerning ventilometry, higher values were found in the post-test when compared with the recovery period.
In the experiment with the mask on, the variables heart rate and ventilometry were significantly higher in the post-test than in the pre-test. Moreover, lower values were found in the recovery period when compared with the post-test. Regarding dyspnea, the values of the Borg's scale were significantly higher in the post-test, with reduction in the recovery period.
The interaction between groups (with and without use of the mask) and the evaluation period (pre-test, post, test and recovery) were significant for the variables dyspnea, oxygen saturation and ventilometry. The association between these factors demonstrated that 35.4% of the alteration in the Borg's scale may be explained by the interaction between group and period. These associations were of 14.2% and 21.1% for the variables oxygen saturation and ventilometry, respectively.
Mean age and standard deviation of the study were of 50.57 ± 11.08 years, similar to the ones found in many studies which involved patients with HF in many functional classes: 36-68 years, FC II and III17; 53 ± 2 years, FC II and III18; 55 ± 11 years, FC IV19 ; 34-90 years, FC II and III20. The distribution per gender in our study was 23 men (82.14%) and five women (17.86%), similar to the important male predominance verified in many studies16,20. The left ventricular ejection fraction (LVEF), which is a measurement of the left cardiac function, main determinant of the heart performance and cardiovascular morbimortality21 obtained mean of 27.14% ± 6.86; similar to the one found in many studies 22,23.
Concerning the 6'WT, the distances walked with and without the use of EPAP presented values below the expectation, demonstrating the low functional capacity of the evaluated patients. Although the EPAP application is a therapeutic alternative which provides effects such as variation in intra-alveolar pressure, increase of functional residual capacity (FRC), redistribution of the extravascular liquid and decrease of intrapulmonary shunt24,25, its use in the 6'WT did not faithfully reflect the real physiological situation in hemodynamic and ventilator terms in this scenario.
The 6'WT has the aim to evaluate both the functional status of the cardiovascular and/or respiratory system and the effects of a therapeutic and rehabilitation program 25,26. Such fact stresses the idea that the adopted strategy (6'WT) was not eficiente in improving the pulmonar congestion and ventilatory dynamics for being an evaluation method, compromising hence the EPAP use in patients with HF. However, the EPAP mask use associated with continuous training and supervised in programs of cardiovascular rehabilitation will be able to lead us to another long-term closing concerning pulmonary function 25.
A hypothesis to explain the lack of increment in the functional capacity with the use of the EPAP mask would be the good compensation status reached through the optimized clinical treatment, making it difficult to reach benefits with the tested strategy.
In the immediate post-test, it was verified that the oxygen arterial saturation (SatO2) was significantly higher in the group which used the mask compared with the one which did not. Although the findings in the evaluated variables had reached statistical significance, the clinical implication of this technique is questionable, since all participants already presented stable basal variables. In a study with patients with COPD, the mean of basal saturation was lower in the pre-test (93.6 ± 5.1%) with significant improvement in the post-test with EPAP (95.4 ± 3.2%)27. Patients with COPD who were evaluated under the use of similar device, with imposition of expiratory resistive load (ERL), presented non-significant improvement in the oxygen saturation27. Van der Schans et al., when using EPAP in exertion, found out significantly lower oxygen consumption (VO2) and carbonic gas production (VCO2) with the use of the mask, with decrease in the Borg's scale after use of EPAP, though. In our study, the perceived exertion through the Borg's scale evidenced significantly higher values in the patients who performed walk with the use of the mask (Md = 4) when compared with the patients who did not use the mask (Md = 2), justified by the expiration performed against pressoric resistance, making difficult the work and ventilator mechanics at the moment of the walk test.
These findings corroborate other studies with patients with COPD in 6'WT performance under use of PEP (positive expiratory pressure) during exercise28. Conversely, in a study which compared CRM post-surgery patients, COPD patients under use of EPAP, there was reduction of dyspnea perception and tiredness with the use of the mask29. The same fact was verified in a population with sleep obstructive apnea, with reduction of respiratory frequency after use of EPAP9 and in patients with COPD, in which electromyographic activity of the accessory muscles was assessed with the use of EPAP26.
Concerning the ventilometry data, the EPAP application may determine increase in ventilatory work which is proportional to the level of PEEP applied.
Regarding the increase of the hemodynamic variables (heart rate and systolic blood pressure) in the post-test verified in the patients with and without EPAP use, they demonstrate expected physiological increase due to the effort performed during the 6'WT.
Thus, our outcomes demonstrate that the use of the EPAP mask increases the respiratory exertion, verified through the Borg's scale and ventilometry, and promotes increase in the oxygen saturation; however, it did not increase the distance walked in the 6'WT, suggesting hence that the usual applicability of the EPAP mask in cardiovascular rehabilitation programs based on our data, generates the need for further investigation both concerning the modality of activity applied and the application of different EPAP pressoric levels.
2. World Health Organization. World Health Statistics. Genebra; 2008. [ Links ]
3. Ribeiro JP, Chiappa GR, Neder JA, Frankenstein L. Respiratory muscle function and exercise intolerance in heart failure. Curr Heart Fail Rep 2009;6:95-101. [ Links ]
4. Frankestein L, Meyer FJ, Sigg C, Nelles M, Schellberg D, Remppis A, et al. Is serial determination of inspiratory muscle strongth o useful prognostic marker in chronic failure? Eur J Cardiovasc Prev Rehab 2008;15:156-61. [ Links ]
5. Rondon MUP. Exercício físico e insuficiência cardíaca. Rev Soc Cardiol Estado de São Paulo 2001;10:273-84. [ Links ]
6. Silva FMF, Bagnali MES, Zardo TS, Bovi A, Carvalho EM, Lopes CR. Repercussões hemodinâmicas e ventilatórias em indivíduos sadios com diferentes níveis de EPAP. Fisioter Mov 2009;22:419-29. [ Links ]
7. Haeffener MP, Ferreira GM, Barreto SS, Arena R, Dall'Ago P. Incentive spirometry with expiratory positive airway pressure reduces pulmonary complications, improves pulmonary function and 6-minute walk distance in patients undergoing coronary artery bypass graft surgery. Am Heart J 2008 Nov;156(5):900.e1-900.e8. [ Links ]
8. Freitas FS, Silva LCR, Tavares LD, Barroso EF, Silva MC, Godoi RL. Aplicação da Pressão Positiva Expiratória nas Vias Aéreas (EPAP): existe um consenso? Fisioter Mov 2009;22:281-92. [ Links ]
9. Heinzer R, White DP, Malhotra T. Effect of expiratory positive airway pressure on sleep disordered breathing. SLEEP 2008;31:429-32. [ Links ]
10. Cardoso F, Tufanin AT, Colucci M, Nascimento O, Jardim JR. Replacement of the 6-min walk test with maximal oxygen consumption in the BODE index applied to patients with COPD: an equivalency study. Chest 2007;132;477-82. [ Links ]
11. Olsson LG, Swedberg K, Clark AL, Witte KK, Cleland JG. Six minute corridor walk test as an outcome measure for the assessment of treatment in randomized, blinded intervention trials of chronic heart failure: a systematic review. European Heart Journal 2005;26:778-93. [ Links ]
12. Guimarães GV, Bellotti G, Bacal F, Mocelin A, Bocchi EA. Pode o teste ergométrico de caminhada de seis minutos ser representativo das atividades habituais do paciente? Arq Bras Cardiol 2002;78:553-6. [ Links ]
13. Carvalho EEC, Costa DC, Crescênio JC, De Santi GL, Papa V, Marques F, et al. Heart Failure: Comparison between Six-Minute Walk Test and Cardiopulmonary Test. Arq Bras Cardiol 2011;97:59-64. [ Links ]
14. Martinez JAB, Padua AI, Terra Filho J. Dyspnea. Medicina (Ribeirão Preto) 2004;37:199-207. [ Links ]
15. AMERICAN THORACIC SOCIETY. ATS Statement: Guidelines for the Six-Minute Walk Test. Am J Respir Crit Care Med 2002;166:111-7. [ Links ]
16. Britto RR, Soares SS, Lima MP. The use of the six minute walk test in the evaluation and follow-up of patients with chronic heart failure: literature review. Rev Soc Cardiol Estado de São Paulo 2004;6 Supl A:10-20. [ Links ]
17. Lipkin DP, Scriven AJ, Crake T, Poole-Wilson PA. Six minute walking test for assessing exercise capacity in chronic heart failure. Br Med J (Clin Res Ed) 1986;292:653-5. [ Links ]
18. Meyer K, Schwaibold M, Westbrook S, Beneke R, Hajric R, Lehmann M, et al. Effects of exercise training and activity restriction on 6-minute walking test performance in patients with chronic heart failure. Am Heart J 1997;133:447-53. [ Links ]
19. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics – 2011 update: a report from the American Heart Association. Circulation 2011;123:e18-209. [ Links ]
20. Araújo DV, Tavares LR, Veríssimo R, Ferraz MB, Mesquita ET. Custo da insuficiência cardíaca no Sistema Único de Saúde. Arq Bras Cardiol 2005;84:422-7. [ Links ]
21. Cintron G, Johnson G, Francis G, Cobb F, Cohn JN. Prognostic significance of serial changes in left ventricular ejection fraction in patients with congestive heart failure. The V-HeFT VA Cooperative Studies Group. Circulation 1993;87(6 Suppl):VI17-23. [ Links ]
22. Winkelmann ER, Chiappa GR, Lima CO, Viecili PR, Stein R, Ribeiro JP. Addition of inspiratory muscle training to aerobic training improves cardiorrespiratory responses to exercise in patients with heart failure and inspiratory muscle weakness. Am Heart J 2009;158:768e1-768e7. [ Links ]
23. Dall'Ago P, Chiappa GR, Guths H, Stein R, Ribeiro JP. Inspiratory muscle training in patient with heart failure and inspiratory muscle weakness. J Am Coll Cardiol 2006;47:757-63. [ Links ]
24. Keteyian SJ. Exercise in the management of patients with chronic heart failure. Curr Heart Fail Rep 2010;7:35-41. [ Links ]
25. Pires SR, Oliveira AC, Parreira VF, Britto RR. Teste de caminhada de seis minutos em diferentes faixas estarias e índices de massa corporal. Rev Bras Fisioterapia 2007;11;147-51. [ Links ]
26. Cardoso DM, Paiva DN, Albuquerque IM, Jost RT, Paixão AV. Effects of expiratory positive airway pressure on the electromyographic activity of accessory inspiratory muscles in COPD patients. J Bras Pneumol 2011;37:46-53. [ Links ]
27. Thompson WH, Carvalho P, Souza JP, Charan NB. Effect of expiratory resistive loading on the noninvasive tension-time index in COPD. J Appl Physiol 2000;89:2007-14. [ Links ]
28. Van der Schans CP, de Jong W, de Vries G, Kaan WA, Postma DS, Koëter GH, et al. Effects of positive expiratory pressure breathing during exercise in patients with COPD. Chest 1994;105;782-9. [ Links ]
29. Ferreira GM, Haeffner MP, Barreto SS, Dall'Ago P. Incentive spirometry with expiratory positive airway pressure brings benefits after myocardial revascularization. Arq Bras Cardiol 2010;94:230-5. [ Links ]
Rua Adolfo Donato da Silva, S/N – Praia Comprida
88103-901 – São José, SC, Brasil
All authors have declared there is not any potential conflict of interests concerning this article.
Sociedade Brasileira de Medicina do Exercício e do Esporte
Av. Brigadeiro Luís Antônio, 278, 6º and.
01318-901 São Paulo SP
Tel.: +55 11 3106-7544
Fax: +55 11 3106-8611